Tratos believed that the solution to Tiberium could be found in the Tacitus, the alien data matrix vital to Kane's plan. To make matters worse, the mutant antigen developed by Tratos and tested on Umagon turned out to be a failure, and the latter was driven insane by her mutation. Meanwhile, even though the Global Defense Initiative has won the war against Nod, they were losing the war against Tiberium, which continued to spread unchecked, poisoning the Earth.
With the apparent death of Kane, the Brotherhood of Nod fractured as the generals of the Inner Circle each vied for power and Anton Slavik, Kane's right-hand man, struggled to maintain control.
